The Ivarsson lab is focusing on the discovery and the characterization of interactions involving short linear motifs, which are typically 3-10 amino acid stretches. We aim to contribute with information novel information on the the human interactome in health and diseases. We develop and use proteomic peptide phage display (ProP-PD) to explore motif-based interactions on a proteome-wide scale.
Our research is interdisciplinary and combines biochemical and biophysical methods with bioinformatics and cell-based assays. In particular, we use proteomic peptide phage display to identify interactions of potential biological relevance, bioinformatics to filter for relevant binders and in vitro affinity measurements and cell-based assays for detailed analysis of key interactions.
We also explore how virus hijack motif-based interactions to turn the cell into a virus producing factory.